Effects of Oxytocin and Carbetocin on Haemostatic Variables in Pregnant Women after Cesarean Section

The article aimed to evaluate if two uterotonic agents -carbetocin and oxytocin- provoke a different activation of the coagulation system in a clinical condition already known to be associated with significant changes of haemostasis. Moreover, the incidence of bleeding and thromboembolic events were evaluated. This observational study shows a similar action of carbetocin compared to oxytocin on haemostatic system. Even if additional trials are necessary to confirm these preliminary data, this study suggests that carbetocin could be as safe as oxytocin in term of haemostatic action on patients already known to be at risk not only for bleeding but also for thromboembolic events in the post-partum and puerperium.

Click here to view PDF and FULLTEXT

Click here to view Gynecology Research Journal