Molecular Mechanisms of Mismatch Repair Genes in Cancer – A Brief Review

The DNA mismatch repair (MMR) system is necessary for the maintenance of genomic stability. The MMR system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops (IDLs) and heterologies generated during DNA replication and recombination.Failure to accomplish these functions may lead to cancer and are associated with tumor prone phenotypes. MMR proteinscoordinate a complex network of physical and functional interactions and are also involved in activation of cell-cycle check point andinduction of apoptosis during DNA damage. They also play a role in cell death by alkylating agents and other chemotherapeutic drugs.
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Gastric Type Adenocarcinoma with Fundic Gland Differentiation in the Duodenum Resected by ESD (Endoscopic Submucosal Dissection)

Gastric type adenocarcinoma with fundic gland differentiation (GA-FG) has been reported as a new, rare, chief celldifferentiation composed carcinoma. Clinicopathologically, it exists on the gastric cardia/fundus, with low proliferative activity andlow-grade malignancy. Until now, there has been no report of this GA-FG type cancer in the duodenum.


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Effects of Transfer Point Glucan #300 Supplementation on Children exposed to Passive Smoking - Placebo-driven Double-blind Clinical Trials

In this study, we focused on the effect of β-glucan supplementation of children with chronic respiratory problems. We measured thelevels of cortisol, salivary IgE and cotinine in 56 children and evaluated the effect of 30 day supplementation with 100 mg/day oraldose of yeast-derived β-glucan. Our results showed strong decrease of cotinine and cortisol levels in saliva of β-glucan-supplementedchildren. The increase of total salivary IgE levels in both groups was not statistically significant. The positive effects of complex curative
treatment using β-glucan were accompanied by increased physical endurance and by significant reduction of negative clinical problems of affected children.


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Association between Stress and Dietary Behaviours among Undergraduate Students in Kuwait: Gender Differences

Studies have shown that a significant proportion of university students globally suffer from stress. Although many studieshave reported an association between psychological stress and dietary behaviour, findings remain inconclusive. To date, no research in Kuwait has assessed the prevalence of stress and its relationship with dietary pattern among university students.


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Does Physical Activity and Sport Practice Lead to a Healthier Lifestyle and Eating Habits in Male Adolescents?

The prevalence of childhood obesity has been increasing rapidly and there is general consensus that good nutritionalpractices and physical activity should be encouraged as early as possible in life. The aim of this study was to describe and to compare the current lifestyle and dietary pattern of normal weight (NW) and overweight + obese (OW+OB) male adolescents who are physically active.


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Parenteral Nutrition Utilization in Bone Marrow Transplant Recipients

Bone marrow transplant (BMT) recipients often require parenteral nutrition (PN) to meet their nutrient needs. While general guidelinesfor the provision of PN support by nutrition support teams (NSTs) have been shown to decrease inappropriate PN use, recommendationsfor nutrition in BMT recipients are lacking. We reviewed the charts of patients status post BMT on PN to determinewhether institutional guidelines for PN initiation and continuous supervision of NSTs could be applied in this population. With theInstitutional Review Board (IRB) approval, charts of adult BMT recipients on PN between June 14, 2006 and June 30, 2007 were examined.Sixty-nine charts were reviewed. Indications for initiation of PN included severe mucositis, graft versus host disease (GVHD), and other transplant related side effects resulting in poor oral intake.



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Overweight, Obesity and Abdominal Obesity in Primary School Children in Pavia, Northern Italy

Childhood obesity has been described as the main health-related problem in developed countries, due to its link with physical, social and psychological consequences with an increased risk for developing metabolic and cardiovascular diseases in adulthood.All the pupils of both sexes attending the second year of all the primary schools in Pavia, Northern Italy, were recruited (n=470) for this study. Measurements of weight, height and waist circumference (WC) were taken under standard conditions. Body Mass Index (BMI) and waist-to-height-ratio (W/HtR) were computed and sex specific percentile values for BMI, WC and W/HtR were calculated and compared with the same percentiles available for different countries.



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