48-years old man was found dead at home, lying in his bed. There was a bucket with liquid vomited remnants with no addition of fresh or digested blood found near the bed and an empty bottle of alkaline mineral water often used to attenuate the gastric pain. Up to the information from the man's relative, he was a chronic alcohol consumer, being last seen alive the day before in the pub, drinking small amount of beer. His personal anamnesis was negative for the previous injuries or any pathological entity which could have potential fatal outcome. External observation of the body did not uncover any signs of mechanical violence on the body. The only pathological findings at the autopsy were: very mild generalised atherosclerosis without stenosis of blood vessels, configuration of the heart with the weight of 400 g was physiological, with no signs of chronic venostatic changes on the internal organs.
Headspace GC-MS Detection of Carbon Monoxide in Decomposed Blood and Hepatic Tissues
Here in a systematic, accurate and reliable method, Head-Space Gas Chromatography-Mass Spectrometry (HS-GC/MS) was developed to determine blood carboxyhemoglobin (COHb%), in order to investigate deaths related to CO exposure especially involving blood and hepatic tissues. Using a column packed with molecular sieve, COHb levels were quantified down to 0.2% in small blood samples quickly and showed good reproducibility with RSD of the COHb < 1%. COHb% in hepatic samples stored at different temperatures (-20 °C for 1- 2 years, 0 °C, and 18 °C for two months) can be determined even when the samples are decomposed.
Identification of Designer Drugs using Gas Chromatography High-Resolution Mass Spectrometry and A Soft-Ionization Source
A small set of amphetamines has been analyzed by gas chromatography (GC) high-resolution time-of-flight mass spectrometry (TOFMS) using a microplasma photoionization (MPPI) soft-ionization source. This plasma-based, wavelength selectable ionization source enables ionization of the test compounds and their corresponding derivatives at ~8-12 eV that is a softer alternative to electron ionization at 70 eV. Three plasma gases were used in this study: Xe plasma that emits photons at resonance lines of 9.57 eV and 8.44 eV; Kr plasma at 10.63 eV and 10.02 eV, and Ar plasma at 11.82 eV and 11.61 eV.
Reduction of Bitterness and Enhancing Palatability of Cetirizine Oral Liquid Dosage Forms by Cyclodextrins
The aim of this manuscript is to study cyclodextrins (CDs) as a potential excipient to suppress bitterness and enhance palatability of pediatric liquid preparations for Cetirizine, an extremely bitter drug. Natural α, β and γ CDs; and β CD derivatives such as hydroxyl propyl (HP), randomly methylated (RM) and sulfobutyl ether (SBE) β-CDs were screened in different molar ratios of 1:1, 1:2 and 1:3 for their inhibition of the extremely bitter taste of Cetirizine using the human gustatory sensation test. Cavity size and chemical substitution are dominantly two factors that affect Cetirizine inclusion into natural CDs and β CD derivatives respectively. Syrup and drops formulations were prepared based on the selected α-, γ -and RM β-CDs.
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Esophageal Cancer and Bisphosphonates
At the beginning of 2009, Dianne Wysowski of the US Food and Drug Administration summarized 23 reports of esophageal cancer following alendronate use. Wysowski also noted that there had been 31 cases following alendronate use in Europe and Japan and ten cases in which other bisphosphonates had been reported as concomitant or suspect treatment. Median time from exposure to diagnosis had been 2.1 years in the US and 1.3 years in Europe. In the two series, 12 cases with histological information had adenocarcinoma and six had squamous cell carcinoma. Wysowski suggested that oral bisphosphonates should be investigated as a risk factor for esophageal cancer.
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Flexural Strength of Provisional Crown and Fixed Partial Denture Resins both with and without Reinforced Fiber
Fabrication of provisional restorations is an important procedure in fixed prosthodontics. Provisional restorations must satisfy the requirements of pulpal protection, positional stability, occlusal function, ability to be cleansed; margin accuracy, wear resistance, strength, and esthetics. The strength of a material can be a determinant of how well these requirements are met. Flexural strength, also known as transverse strength, is a measurement of the strength of a bar (supported at each end) under a static load. The flexural strength test is a combination of tensile and compressive strength tests and includes elements of proportional limit and elastic modulus measurements
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The Ni(II) Complex of 2-Hydroxy-Pyridine-N-Oxide 2-Isothionate: Synthesis, Characterization, Biological Studies, and X-ray Crystal Structures using (1) Cu Kα Data and (2) Synchrotron Data
C12H20N6NiO6S2 or NiL2(SCN)2](NH4)2.2H2O, where L is 2-hydroxy-pyridine-N-oxide, has been prepared and characterized using elemental analyses, IR, UV and visible spectrometry, magnetic moment measurements, thermal analyses and single crystal X-ray analyis. The results indicate that the complex reacts as a bidentate ligand and is bound to the metal ion via the two oxygen atoms of the ligand (HL). The activation energies, ΔE*, entropies ΔS*, enthalpies ΔH* and order of reactions have been derived from differential thermo-gravimetric (DTA) curves.
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